inflammatory phenotype – Communicable Diseases Research

Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis

SARS-CoV-2에 의한 폐 감염은 심각한 COVID-19에서 염증성 표현형과 함께 노화를 유도합니다: 바이러스 돌연변이 유발 가능성

Article

Published on 2022-08-182022-09-11
Journal: The European Respiratory Journal
[Category] Fulltext, SARS, 진단, 치료기술,

The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling

SARS-CoV-2의 스파이크 단백질은 인테그린 α5β1 및 NF-κB 신호 전달을 통해 내피 염증을 유도합니다

Article

Published on 2022-03-012022-09-11
Journal: The Journal of Biological Chemistry
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] ACE2 activate Activation addition adhesion Adhesion Molecule administration bind Blood Capillaries CD45 Coagulation coagulation factor Coagulation factors COVID-19 Critical Cytokines dependent on domain dysfunction dysregulated edema Effects endothelial Endothelial cell endothelial cells Endothelial dysfunction expression FVIII hallmark hallmarks homeostasis ICAM1 IL-1β IL-6 in vivo increased expression Incubation induce Inflammation inflammatory phenotype inhibitor inhibitors integrin intravenous Intravenous administration intravitreal injection kidney leukocyte leukocytes liver lung maintain mechanism motif NF-κB NF-κB signaling nuclear translocation occur Peripheral blood peripheral blood leukocyte peripheral blood leukocytes permeability prevented Proinflammatory cytokine proinflammatory cytokines Receptor-binding domain responsible SARS-CoV-2 severe disease Signaling Spike protein spike protein of SARS-CoV-2 spike protein. subsequent target gene the receptor-binding domain the spike protein tissue tissues TNFα umbilical umbilical vein vascular effect vascular endothelial cells vascular inflammation vascular leakage VCAM1
[DOI] 10.1016/j.jbc.2022.101695 PMC 바로가기 [Article Type] Article

Multiomics integration-based molecular characterizations of COVID-19

COVID-19의 다중 유학 통합 기반 분자 특성

Review

Published on 2022-01-022022-09-01
Journal: Briefings in Bioinformatics
[Category] SARS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 caused complex Consequences contributing to coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 diagnostics disease pathogenesis Genetic variation Genomics Health help Host immune immunomics include inflammatory phenotype insight integration knowledge mechanism metabolomics molecular molecular characteristics multiomics multiomics integration offer outcome pandemic Pathogenesis pathogenesis of SARS-CoV-2 proteomics puzzle respiratory responses risk stratification SARS-CoV-2 severe acute respiratory syndrome Coronavirus severity single-cell omics Systems biology target targets therapeutic traits transcriptomics unique Vaccine development virulence virus
[DOI] 10.1093/bib/bbab485 PMC 바로가기 [Article Type] Review

A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune–epithelial interface

420

Published on 2021-12-282022-10-29
Journal: Proceedings of the National Academy of Sciences of
[Category] COVID-19,

[키워드] acute respiratory syndrome age B cells Blood children Coronavirus-2 COVID-19 COVID-19 patients cross-talk Cytokine storm deviation Ebola elicit encodes epithelia epithelial epithelial cell Express Factors fraction gene cluster hallmark healthy children Immune cell immune cells immune dysregulation induce infected with SARS-CoV-2 Inflammatory inflammatory phenotype influenza A initial Interaction interferon lung manifestation monocyte multiorgan failure myeloid cell nonstructural proteins pathogenic viruses Patient Perturbation Pneumonia Protein provide provoke reported SARS-CoV-2 SARS-CoV-2 protein severe COVID-19 severe disease Significance spike systemic inflammation transcriptional transduced virus
[DOI] 10.1073/pnas.2116853118 PMC 바로가기 [Article Type] 420

Unraveling the Relationship of Asthma and COVID-19

Review

Published on 2021-12-162022-10-30
Journal: Journal of Personalized Medicine
[Category] COVID-19,

Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host

임상 관행은 COVID-19 환자의 호흡기 미생물군유전체 구성 및 숙주와의 상호작용의 기초가 됩니다

Article

Published on 2021-10-292022-09-10
Journal: Nature Communications
[Category] MERS, SARS, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법,

[키워드] antibiotic association Bacteria changes in clinical clinical microbiology Community condition confounder confounders contribute contributing to Control COVID-19 COVID-19 patient COVID-19 patients Disease progression driving Evidence exacerbated explain Host ICU identify immune cells immune response immune responses Infection inflammatory markers inflammatory phenotype intensive care intensive care unit Interaction Lower respiratory tract Lungs mechanical ventilation Microbiome microbiome composition microbiota oxygen oxygen support pathology physical physically proinflammatory reduced Research respiratory respiratory tract SARS-CoV-2 viral load Sequencing severe COVID-19 patients severe disease Single-cell transcriptomics Treatment underlie understanding upper respiratory tract Variation Viral Viral load with COVID-19
[DOI] 10.1038/s41467-021-26500-8 PMC 바로가기 [Article Type] Article

Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection

차등 혈장 세포질 수지상 세포 표현형 및 무증상 및 심한 COVID-19 감염에서 I 형 인터페론 반응

Research Article

Published on 2021-09-022022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, SARS, 유전자 메커니즘,

[키워드] absence accompanied adaptive immune responses Anti-viral anti-viral IFN anti-viral response antiviral responses Asymptomatic asymptomatic SARS-CoV-2 infected subjects Cell cells cellular characterized chemokine chemokines circulating contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 patient Critically ill Critically ill patient critically ill patients cytokine Cytokine storm Cytokines death Defense dendritic cell dendritic cells disease severity early phase elevated ENhance epithelial cells event Evidence Ex vivo expression fine-tune Frequency hospitalized patient hospitalized patients Host host defense Host-directed therapies host-directed therapy human peripheral blood mononuclear cell IFN IFN-stimulated gene Immune cell immune cells immune responses Immunity IMPROVE in vitro induce Infection Inflammatory cytokine Inflammatory cytokines inflammatory phenotype inhibiting viral replication Innate innate immune response Innate immunity Interaction interferon interferons investigated low frequency Lung epithelial cells mechanism mononuclear cell multi-organ failure neuropilin observation Pathogenesis PBMC PD-L1 marker pDC/type I IFN axis Peripheral blood pharmacological strategy phenotype plasmacytoid dendritic cell plasmacytoid dendritic cells pro-inflammatory cytokine pro-inflammatory cytokines producing productive viral replication progression protective role regulate Regulation released responsible resulting SARS-CoV-2 SARS-CoV-2 infected subject SARS-COV-2 infection SARS-CoV-2 pandemic secreted secretion serum severe COVID-19 Severe COVID-19 Infection severe COVID-19 patients stratified the cytokine storm the interferon tissue damage TLR7/8 type I type I and III IFNs type I and III interferons Type I IFN type I IFN producing cells Viral viral replication Viral resistance virus viruses
[DOI] 10.1371/journal.ppat.1009878 PMC 바로가기 [Article Type] Research Article

Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins

렉틴 경로는 SARS-CoV-2 단백질에 의한 보체 활성화를 매개합니다

Immunology

Published on 2021-07-052022-09-11
Journal: Frontiers in Immunology
[Category] SARS, 바이오마커,

[키워드] activate Activation acute respiratory distress acute respiratory distress syndrome addition antibody antiviral drug antiviral drugs ARDS bind block C3b cause Cell cell surface cellular clinical trials complement Complement activation Complement activation product Complement activation products complement system Corticosteroid Corticosteroids COVID-19 Critical cytokine Cytokine storm disease severity early stage early stages Efficacy endothelial injury enzyme event expressing FACS analyses FACS analysis HEK-293 cell HEK-293 cells immune system Infection inflammatory phenotype Inflammatory response inhibited inhibition inhibitor inhibitory Innate immunity lectin lectin pathway maintenance MASP-2 microangiopathy monoclonal antibody N-protein Narsoplimab Pathogenesis pathogenesis of COVID-19 pathology pathophysiological Patient progressed proinflammatory provide respiratory distress Respiratory distress syndrome robust S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2 S protein severe COVID-19 shifting shown subsequent syndrome targeting the cell the cytokine storm therapeutic efficacy Treatment triggering
[DOI] 10.3389/fimmu.2021.714511 PMC 바로가기 [Article Type] Immunology

Aging, Immunity, and COVID-19: How Age Influences the Host Immune Response to Coronavirus Infections?

Physiology

Published on 2021-01-122022-10-31
Journal: Frontiers in Physiology
[Category] COVID-19,

[키워드] acute respiratory syndrome Adaptive immune response Affect aging cause Cell change changes in Clinical outcome Comorbidities condition contribute coronavirus COVID-19 death determine disease Disease progression Diseases effective response feature help Host immune response illness Immune cell immune dysfunction immune response immune system Immunity immunosenescence Infection infections Infectious disease Inflamm-aging inflammatory phenotype influence lymphoid management Novel coronavirus pandemic pathophysiology peripheral tissues Quantitative respiratory infection response SARS-CoV senescent susceptibility Vaccine Vaccines
[DOI] 10.3389/fphys.2020.571416 PMC 바로가기 [Article Type] Physiology

Effect of Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia: A Randomized Clinical Trial

COVID-19 폐렴으로 입원한 환자의 임상 악화에 대한 Tocilizumab 대 표준 치료의 효과: 무작위 임상 시험

Randomized Controlled Trial

Published on 2021-01-012022-09-12
Journal: JAMA Internal Medicine
[Category] 임상, 진단,

[키워드] 95% CI age benefit blinded C-reactive protein causes clinical Clinical Center control arm control group coronavirus disease COVID-19 criteria death defined died Disease progression Effect elevated EudraCT evaluate evaluate the effect experimental arm experimental group Fever fraction groups hospital Hospitalized inflammatory phenotype intensive care Intention-to-treat analyses interim analysis interquartile range intravenous tocilizumab Intubated Invasive mechanical ventilation Italy less majority male median Nasopharyngeal swab NCT04346355 Open-label outcome oxygen pandemic Patient patients hospitalized patients with COVID-19 placebo-controlled Pneumonia polymerase chain Prospective protocol radiologic imaging randomization Randomized randomized clinical trial randomized patient receive Retrospective study safety profile second dose shown Stage Standard standard care standard care group Standard of care Standard therapy supportive care the disease therapy Tocilizumab tocilizumab administration Trial Two patient with COVID-19 worsening
[DOI] 10.1001/jamainternmed.2020.6615 PMC 바로가기 [Article Type] Randomized Controlled Trial